Bhabha Lab
PDBs rendered by Xiaowei Yan

PDBs rendered by Xiaowei Yan

 

From atoms to cells to organisms, life is in constant motion. All cells face the challenge of transporting molecules from one location to another within the cell, and this is essential for the cell to function normally. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. We use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are so spectacularly coordinated in normal cells, and what goes wrong when they break.