RESEARCH and review articles

 

1: Ekiert DC*, Bhabha G*, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, 

Vale RD. Architectures of Lipid Transport Systems for the Bacterial Outer

Membrane. Cell. 2017 Apr 6;169(2):273-285.e17. doi: 10.1016/j.cell.2017.03.019.

PubMed PMID: 28388411.

 

2: Bhabha G, Johnson GT, Schroeder CM, Vale RD. How Dynein Moves Along

Microtubules. Trends Biochem Sci. 2016 Jan;41(1):94-105. doi:

10.1016/j.tibs.2015.11.004. Review. PubMed PMID: 26678005; PubMed Central PMCID: 

PMC4706479.

 

3: Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura

GL, Tainer JA, Baker D. Exploring the repeat protein universe through

computational protein design. Nature. 2015 Dec 24;528(7583):580-4. doi:

10.1038/nature16162. PubMed PMID: 26675729; PubMed Central PMCID: PMC4845728.

 

4: Bhabha G, Biel JT, Fraser JS. Keep on moving: discovering and perturbing the

conformational dynamics of enzymes. Acc Chem Res. 2015 Feb 17;48(2):423-30. doi: 

10.1021/ar5003158. Review. PubMed PMID: 25539415; PubMed Central PMCID:

PMC4334266.

 

5: Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD.

Allosteric communication in the dynein motor domain. Cell. 2014 Nov

6;159(4):857-68. doi: 10.1016/j.cell.2014.10.018. PubMed PMID: 25417161; PubMed

Central PMCID: PMC4269335.

 

6: Liu Y, Zhang X, Tan YL, Bhabha G, Ekiert DC, Kipnis Y, Bjelic S, Baker D,

Kelly JW. De novo-designed enzymes as small-molecule-regulated fluorescence

imaging tags and fluorescent reporters. J Am Chem Soc. 2014 Sep

24;136(38):13102-5. doi: 10.1021/ja5056356. PubMed PMID: 25209927; PubMed Central

PMCID: PMC4183642.

 

7: McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. Activation of

cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014

Jul 18;345(6194):337-41. doi: 10.1126/science.1254198. PubMed PMID: 25035494;

PubMed Central PMCID: PMC4224444.

 

8: Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y,

Bjelic S, Baker D, Kelly JW. Small molecule probes to quantify the functional

fraction of a specific protein in a cell with minimal folding equilibrium shifts.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4449-54. doi:

10.1073/pnas.1323268111. PubMed PMID: 24591605; PubMed Central PMCID: PMC3970509.

 

9: Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek

J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC,

Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward

AB, Goudsmit J, Wilson IA. A common solution to group 2 influenza virus

neutralization. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):445-50. doi:

10.1073/pnas.1319058110. PubMed PMID: 24335589; PubMed Central PMCID: PMC3890827.

 

10: Bhabha G, Ekiert DC, Jennewein M, Zmasek CM, Tuttle LM, Kroon G, Dyson HJ,

Godzik A, Wilson IA, Wright PE. Divergent evolution of protein conformational

dynamics in dihydrofolate reductase. Nat Struct Mol Biol. 2013 Nov;20(11):1243-9.

doi: 10.1038/nsmb.2676. PubMed PMID: 24077226; PubMed Central PMCID: PMC3823643.

 

11: van den Bedem H, Bhabha G, Yang K, Wright PE, Fraser JS. Automated

identification of functional dynamic contact networks from X-ray crystallography.

Nat Methods. 2013 Sep;10(9):896-902. doi: 10.1038/nmeth.2592. PubMed PMID:

23913260; PubMed Central PMCID: PMC3760795.

 

12: Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon

MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R,

Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses

mediated by a single antibody loop. Nature. 2012 Sep 27;489(7417):526-32. doi:

10.1038/nature11414. PubMed PMID: 22982990; PubMed Central PMCID: PMC3538848.

 

13: Bhabha G, Tuttle L, Martinez-Yamout MA, Wright PE. Identification of

endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate

reductase by 2D NMR. FEBS Lett. 2011 Nov 16;585(22):3528-32. doi:

10.1016/j.febslet.2011.10.014. PubMed PMID: 22024482; PubMed Central PMCID:

PMC3215841.

 

14: Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox

F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH,

Cornelissen LA, Poon LL, Peiris M, Koudstaal W, Wilson IA, Goudsmit J. A highly

conserved neutralizing epitope on group 2 influenza A viruses. Science. 2011 Aug

12;333(6044):843-50. doi: 10.1126/science.1204839. PubMed PMID: 21737702; PubMed

Central PMCID: PMC3210727.

 

15: Bhabha G, Lee J, Ekiert DC, Gam J, Wilson IA, Dyson HJ, Benkovic SJ, Wright

PE. A dynamic knockout reveals that conformational fluctuations influence the

chemical step of enzyme catalysis. Science. 2011 Apr 8;332(6026):234-8. doi:

10.1126/science.1198542. PubMed PMID: 21474759; PubMed Central PMCID: PMC3151171.

 

16: Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ,

Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as

beta-sheet folding nucleators. Proc Natl Acad Sci U S A. 2009 Jul

7;106(27):11067-72. doi: 10.1073/pnas.0813012106. PubMed PMID: 19541614; PubMed

Central PMCID: PMC2708776.

 

17: Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M,

Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus

epitope. Science. 2009 Apr 10;324(5924):246-51. doi: 10.1126/science.1171491.

PubMed PMID: 19251591; PubMed Central PMCID: PMC2758658.

 

18: Yao Y, Bhabha G, Kroon G, Landes M, Dyson HJ. Structure discrimination for

the C-terminal domain of Escherichia coli trigger factor in solution. J Biomol

NMR. 2008 Jan;40(1):23-30. PubMed PMID: 18043871.

 

19: Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ,

Rockman HA, McNally EM. Reduced life span with heart and muscle dysfunction in

Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 1;16(23):2933-43. PubMed

PMID: 17855453.